Consequences of PPARα Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids

The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid cata...

PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis

Excess dietary lipid generally leads to fat deposition and impaired glucose homeostasis, but consumption of fish oil (FO) alleviates many of these detrimental effects. The beneficial effects of FO are thought to be mediated largely via activation of the nuclear receptor peroxisomal-proliferator-activated receptor α (PPARα) by omega-3 polyunsaturated fatty acids and the resulting upregulation of...

Impacts of different dietary lipid sources on growth performance, fatty acid composition and antioxidant enzyme activity of juvenile Black Sea bream, Acanthopagrus schlegeli

The aim of the present study was to evaluate the impacts of diets supplemented with different lipid sources on growth performance, body composition, fatty acid profile, and hepatic antioxidant enzyme activity of juvenile black sea bream, Acanthopagrus schlegeli (initial mean weight, 1.1±0.02g). Four isonitrogenous and isolipidic diets were formulated with either fish oil (FO), soybean oil (SO),...

Histological and fatty acids changes in Caspian salmon (SalmotruttacaspiusKessler, 1877) fed diets with different levels of vitamins E and highly unsaturated fatty acids (HUFA)

In this study, the combined effect of different levels of dietary n-3 HUFAs with α-Tocopherol on changes in the structure of intestine and pyloric caeca and fatty acids profile of Caspian salmon, Salmotrutta caspius, fry (initial weight of 600 ± 25 mg for 10 weeks) were investigated. Six experimental diets containing three different dietary levels of n-3 HUFAs (Low: 1 + 0.5, DHA+ EPA, Med...